Observation of comet 1905 IV

COMET IV meeting summary

On two sunny days in Rome in November 2014, more than 200 people with an interest in core outcome sets (COS) from around the world gathered at The Pontificia Università Lateranense for the fourth meeting of the COMET Initiative. They came from 14 countries: Austria, Canada, Denmark, France, Germany, Ireland, Italy, Netherlands, Poland, Portugal, Romania, Switzerland, UK and USA. The programme w...

Dmd059121 1890..1905

Subcutaneous injection is an important route of administration for therapeutic proteins that provides several advantages over other modes of parenteral delivery. Despite extensive clinical use, the exact mechanism underlying subcutaneous absorption of proteins is not completely understood, and the accuracy of prediction of absorption of biotherapeutics in humans remains unsatisfactory. This rev...

Dmd065763 1905..1916

Montelukast has been recommended as a selective in vitro and in vivo probe of cytochrome P450 (P450) CYP2C8 activity, but its selectivity toward this enzyme remains unclear. We performed detailed characterization of montelukast metabolism in vitro using human liver microsomes (HLMs), expressed P450s, and uridine 59-diphospho-glucuronosyltransferases (UGTs). Kinetic and inhibition experiments pe...

Phoebus A. Levene, 1905

Some Observation on Nickel(IV) Periodate

Variable temperature EPR spectra of KNilOß • 0.5 H2O have established that the paramagnetic behavior of this compound (~ 1 BM) is due to the presence of nickel(III) atoms which have occupied some nickel(IV) sites in the crystal lattices. Change of spectral pattern from rhombic (77 K) to isotropic (300 K) is due to a dynamic Jahn-Teller effect. Electrical conductivity measurement has shown it to...